Mechanism of action (osteostimulation*)

Effects of bioactive glass S53P4 or beta-tricalcium phosphate and bone morphogenetic protein-2 and bone morphogenetic protein-7 on osteogenic differentiation of human adipose stem cells.
Waselau M, Patrikoski M, Juntunen M, Kujala K, Kääriäinen M, Kuokkanen H, Sándor GK, Vapaavuori O, Suuronen R, Mannerström B, von Rechenberg B, Miettinen S. J Tissue Eng. 2012;3(1).

Osteoblast response to continuous phase macroporous scaffolds under static and dynamic culture conditions.
Meretoja VV, Malin M, Seppälä JV, Närhi TO. J Biomed Mater Res. 2008;89A(2):317-325.

Molecular basis for action of bioactive glasses as bone graft substitute.
Välimäki VV, Aro HT. Scandinavian Journal of Surgery. 2006;95(2):95-102.

Intact surface of bioactive glass S53P4 is resistant to osteoclastic activity.
Wilson T, Parikka V, Holmbom J, Ylänen H, Penttinen R. J Biomed Mater Res. 2005;77A(1):67-74.

Granule size and composition of bioactive glasses affect osteoconduction in rabbit.
Lindfors NC, Aho AJ. J Mater Sci: Mater Med. 2003;14(4):265-372.

Osteoblast differentiation of bone marrow stromal cells cultured on silica gel and sol-gel-derived titania.
Dieudonné SC, van den Dolder J, de Ruijter JE, Paldan H, Peltola T, van ‘t Hof MA, Hap­ponen RP, Jansen JA. Biomaterials. 2002;23(14):3041-3051.

Histomorphometric and molecular biologic comparison of bioactive glass granules and autogenous bone grafts in augmentation of bone defect healing.
Virolainen P, Heikkilä J, Yli-Urpo A, Vuorio E, Aro HT. J Biomed Mater Res. 1997;35A(1):9- 17.

(*non-osteoinduction)